Nucleic Acids, Immunity and Genome Defence


Shizuo Akira

Laboratory of Host Defence, WPI Immunology Frontier Research Center

Osaka University

Mariano Garcia-Blanco

    University of Texas, USA

Victoria Cowling

University of Dundee, UK

Eric Miska

University of Cambridge, UK

Jörg Vogel

Universität Würzburg, Germany

Jan Rehwinkel

University of Oxford, UK

Yuri Motorin

University of Lorraine, France

Michaela Frye

University of Cambridge, UK

Gunther Hartmann

University of Bonn, Germany

Mark Helm

Johannes Gutenberg-University, Mainz, Germany

Yi-Tao Yu

University of Rochester, USA

Jean-Luc Imler

University of Strasbourg, France


Vincent Kelly

Trinity College Dublin, Ireland

Dominique Garcin

University of Geneva, Switzerland

Emiko Uchikawa

EMBL Grenoble, France

Kazuko Nishikura

The Wistar Institute, USA


Pierre Maillard

University College London, UK

Matthias Soller

University of Birmingham, United Kingdom

Rayk Behrendt

Technische Universität Dresden, Germany



Bus leaving from Prague Convention Centre to Brno

Departure at 11:00

Place of departure: parking in front of the Enterance No. 10, Convention Centre

See the map: (map 1, map 2)

The bus doesn´t have wifi and toilets, so be prepared for it.

16:00 Walking city tour of Brno
19:00 Welcome buffet dinner in Siesta Lobby Bar
9:00–9:15  Opening remarks
 9:15 - 10:15 Shizuo Akira - "The control of inflammatory and immune responses by the endoribonuclease Regnase-1"
   SESSION 1: Viruses and RNAi
Chair: Mary O'Connell
10:15 - 10:45 Jean-Luc Imler - "A dedicated siRNA pathway for antiviral immunity in Drosophila"
10:45 - 11:15 Jörg Vogel - "Dual RNA-seq and Single-cell RNA-seq approaches to studying Salmonella pathogenesis"
11:15 - 11:45 Coffee Break
11:45 - 12:15 Pierre Maillard - "Unmasking the antiviral activity of RNA interference in mammalian cells"
12:15 - 12:35 Sara Macias – "INTERFERing with small RNAs"
12:35 - 12:45 Group Photo
12:45 - 14:00 Lunch
  SESSION 2: RNA Modification
Chair: Vincent Kelly
 14:00 - 14:30 Kazuko Nishikura - "ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay"
14:30 - 15:00  Yuri Motorin - "High-throughput profiling of tRNA 2'-O-methylation in Bacteria"
15:00 - 15:30  Yi-Tao Yu - "RNA-guided RNA pseudouridylation and its applications"
15:30 - 16:00 Coffee Break
16:00 – 16:30 Michaela Frye – "Cytosine-5 RNA methylation in stem cells and disease"
16:30 – 17:00 Eric Miska – "Attenuation of RNA viruses through 3’ terminal uridylation of the viral genome"
17:00 – 17:20 David Courtney – "Epitranscriptomic enhancement of influenza A virus gene expression and replication"
17:20 – 17:40 Manuela Ye – "RNA editing signature during myeloid leukemia cell differentiation"
17:40–19:30 Poster Session and Refreshment (room C)


SESSION 3: Nucleic Acid Sensors
Chair:  Jan Rehwinkel
09:00 – 09:30 Emiko Uchikawa - "Structural study of viral RNA detection by Rig-I- like helicases in innate immune system"
09:30 – 10:00 Vincent Kelly - "A loaded GUN: artificial modification of transfer RNA to target autoimmune disease"
10:00 – 10:20 Ashish Dhir – "Mitochondrial double stranded RNA triggers antiviral signalling in humans"
10:20 – 10:40 Rachel Ancar – "Novel RNA end modifications detected by innate immune RNA sensors"
10:40 – 11:10 Coffee Break
11:10 – 11:40 Gunther Hartmann - "Direct RIG-I activation of NK cells triggers TRAIL-dependent cytotoxicity against autologous tumor cells"
11:40 – 12:00 Chun Kim – "RIPK1 prevents ZBP1-mediated necroptosis"
12:00 – 12:20 Florian Ebner - "The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection"
12:20 – 12:40 Mikhail Lebedin – "Molecular barcoding as a tool for error-free antibody repertoire analysis"
12:40 – 14:00  Lunch
       SESSION 4: Nucleic Acid Modification
Chair: Kazuko Nishikura
 14:00 – 14:30 Mark Helm - "How to shirk recognition of RNA by TLR7"
 14:30 – 15:00 Matthias Soller – "m6A mRNA methylation regulates alternative splicing in Drosophila sex determination"
 15:00 – 15:30 Michael Jantsch - "Dissection of ADAR1 as a suppressor of antiviral IFN signaling"
 15:30 – 16:00  Coffee Break
 16:00 – 16:30 Victoria Cowling – "mRNA cap regulation during T cell activation"
 16:30 – 17:00 Anders Virtanen – "Variable penetrance of PARN (poly(A)-specific ribonuclease) loss-of-function (LOF) variants in a three generation pedigree"
 17:30–18:30 Tour of CEITEC
 18:45–20:00 Visit of Mendel Museum
 20:00 - 23:00 Gala dinner in Augustinian Abbey
                                                                                       SESSION 5: Infectious and Inflammatory Disease
Chair: Eric Miska
 09:00 – 09:30 Rayk Behrendt – "The role of endogenous nucleic acids in the initiation of systemic autoimmunity"
 09:30 – 10:00 Liam Keegan – "Evolutionarily conserved biological roles of ADAR RNA editing enzymes"
 10:00 – 10:20

Theopold Ulrich – "Innate immune reactions against wounds and tumors – an insect model"

 10:20 – 10:40 Fujinaga Koh – "Hili inhibits HIV replication in activated T cells"
10:40 – 11:10  Coffee Break
11:10 – 11:25  RNA Society Award
 11:25 – 11:55 Jan Rehwinkel – "Z-RNA sensing by ZBP1/DAI induces necroptosis"
 11:55 – 12:15 Jaclyn Quin – "Major transcriptional changes observed in the Fulani ethnic group less susceptible to malaria are associated with increased expression of non-coding RNAs"
 12:15 - 12:35 Pardi Norbert – "Nucleoside-modified mRNA makes hemagglutinin into a potent universal influenza virus vaccine candidate"
 12:35 - 12:55 Maria Metsger – "Single-cell transcriptome analysis of metabolic stress response in macrophage"
 12:55 - 14:30 Lunch


BEST WESTERN PREMIER Hotel International Brno****


Husova 16, 659 21 Brno, Czech Republic

BEST WESTERN PREMIER Hotel International Brno is a luxury four-star hotel situated beneath Špilberk Castle. It is less than 100 metres from náměstí Svobody (Freedom Square), and is tastefully situated to one side of the historic centre. This important functionalist building from 1962 has been entered onto the list of cultural monuments, and was influenced by pre-war Bauhaus architecture and partly by the Brazilian architect Oscar Niemeyer.

How to get to the International Hotel from the Brno airport?
From bus station Letiště Tuřany (Airport Tuřany) by bus nr. 76 to tram station Hlavní nádraží (Main Railway Station), the change for tram nr. 4 to  tram station Česká.

How to get to the International Hotel from the Main Bus Terminal Zvonařka?
From Zvonařka Main Bus Terminal by tram nr. 12 to tram station Česká.

Useful maps:

From the Main Railway station to the International Hotel
From Česká to  the International Hotel
From the Hotel Grand - Student Agency bus station to the International Hotel




Abstracts and Posters

Book of Abstracts is HERE to download.