Nucleic Acids, Immunity and Genome Defence


Jean - Laurent Casanova

Rockefeller University, USA & Imagine Institute, France


Caetano Reis e Sousa

Cancer Research UK
Lincoln´s Inn Fields Laboratories, UK

Sara Cherry

  University of Pennsylvania, USA

Mariano Garcia-Blanco

    University of Texas, Galveston, USA


Lee Gehrke

Massachusetts Institute of Technology and Harvard Medical School, USA


Reuben Harris

 University of Minnesota, USA


Gunther Hartmann

University of Bonn, Germany


Mark Helm

Johannes Gutenberg-University, Mainz, Germany


Michael Jantsch

University of Vienna, Austria

Nina Papavasiliou

 Rockefeller University, USA


Jan Rehwinkel

University of Oxford, UK


Gideon Rechavi

Tel Aviv University, Israel


Osamu Takeuchi

Kyoto University, Japan


Leonie Unterholzner

University of Dundee, UK


Drew Weissman

University of Pennsylvania, USA


Liam Keegan

Central European Institute of Technology, Czech Republic


Jean-Luc Imler

University of Strasbourg, FR


9:00 - 9:30  Opening Words


09:30 - 10:30 Jean-Laurent Casanova - "Toward a genetic theory of childhood infectious diseases”

SESSION 1: Nucleic Acid Sensors - Chair: Gunther Hartmann

10:30 - 11:00 Lee Gehrke - "RNAs containing modified nucleotides fail to trigger RIG-I conformational changes for innate immune signaling"

11:00 - 11:30 Coffee break

11:30 - 12:00 Leonie Unterholzner - "cGAS and IFI16: Sensing intracellular DNA as 'stranger' and 'danger' signal"

12:00 - 12:30 Jean-Luc Imler - "Sensing viral RNAs in the model organism drosophila

12:30 - 14:00 Lunch


SESSION 2: RNA Modification - Chair: Maria Ohman

14:00 - 14:30 Michael Jantsch - "Understanding the effects of editing-deficiency"

14:30 - 15:00 Mark Helm - "RNA modifications affect recognition and immunestimulation by TLR7"

15:00 - 15:30 Liam Keegan - "Evolutionarily conserved immune effects of ADAR RNA editing, Conflict RNA Modifications and the RNA-DNA genome transition"

15:30 - 16:00 Coffee break 

16:00 - 16:30 Gideon Rechavi - "mRNA modifications beyond RNA editing"

16:30 - 17:00  Mashael Alqasem - "Queuine Insertase tagging and selection in MDA-MB-231 cells via CRISPR and SmartFlare™"

17:00 - 17:30 
Nina Papavasiliou - "RNA editing as a mechanism of diversification of cellular populations"

17:30 - 19:00  Poster Session I 

SESSION 3: Infectious Diseases - Chair: Michael Jantsch

09:00 - 09:30 Mariano Garcia-Blanco - "The RNA helicase DDX39B regulates IL7R alternative splicing reducing the risk of Multiple Sclerosis"

09:30 - 10:00  Ann-Kristin Östlund Farrants - "Transcriptome and DNA methylome analysis of two sympatric 1 ethic groups with 2 differential susceptibility to Plasmodium falciparum infection living in Burkina Faso"

10:00 - 10:30 Yifat Ofir-Birin - "Cell-cell communication between Plasmodium and host immune DNA sensing pathway via exosomes"

10:30 - 11:00 Mayra Diosa-Toro - "Dengue virus-induced ATF4 expression is independent of eiF2α phosphorylation and SG formation"

11: 00 - 11:30 Coffee break


SESSION 4: Nucleic Acids Modification  - Chair: Michael Jantsch

11:30 - 12:00 Reuben Harris - "Cancer Mutagenesis by APOBEC3B and Hypomorphic APOBEC3H"

12:00 - 12:30 Marek Bartošovič - "N6-methyladenosine demethylase FTO targets pre-mRNAs and plays a novel role in nuclear mRNA processing and expression"

12:30 - 14:00 Group Photo and Lunch


SESSION 5: Inflammation -  Chair: Drew Weissman

14:00 - 14:30  Roth Shalom Hillel - "A Computational Screen For RNA Editing Alterations In Autoimmune Diseases"

14:30 - 15:00 Osamu Takeuchi - "Posttranscriptional control of inflammatory responses by Regnase-1 and Roquin"

15:00 - 15:30 Jan Rehwinkel - "SAMHD1 limits activation of the cGAS-STING pathway"

15:30 - 16:00 Coffee break 


SESSION 6: Disease vectors - Chair: Drew Weissman

16:00 - 16:30 Erika Girardi - "Cross-species comparative analysis  of Dicer proteins during Sindbis  virus infection"

16:30 - 17:00 Sara Cherry - "RNA viruses are targeted by diverse RNA binding proteins"

17:00 - 17:30 Susan Schuster- "Using CRISPR/Cas9 to unravel the role of mammalian RNAi in antiviral immunity"

17:30 - 18:30 Poster Session II
19:00               Departure to the Mendel Museum and Abbey
20:00 - 22:00 Gala Dinner

:30 - 09:30   Caetano Reis e Sousa - "Sensing and restriction of RNA viruses"


SESSION 7: - Towards Therapies Chair: Mark Helm

09:30 - 10:00 Gunther Hartmann - "Identification of the minimal ligand motif for the cytoplasmic DNA sensor cGAS"

10:00 - 10:30 Gregory Heikel - "Exploring the role of the RNA-binding activity of the E3 ubiquitin ligase Trim25 in antiviral innate immunity"

10:30 - 11:00 Coffee break 

 11:00 - 11:30 Dmitriy Chudakov - "Unique molecular barcoding in BCR and TCR repertoire profiling"

11:30 - 12:00 Drew Weissman - "Nucleoside-modified mRNA-lipid nanoparticle therapeutic protein delivery platform"

12:00 - 12:30 Poster Award

12:30 - 13:30 Lunch


BEST WESTERN PREMIER Hotel Interantional Brno****

Husova 16, 659 21 Brno, Czech Republic

BEST WESTERN PREMIER Hotel International Brno is a luxury four-star hotel situated beneath Špilberk Castle. It is less than 100 metres from náměstí Svobody (Freedom Square), and is tastefully situated to one side of the historic centre. This important functionalist building from 1962 has been entered onto the list of cultural monuments, and was influenced by pre-war Bauhaus architecture and partly by the Brazilian architect Oscar Niemeyer.


How to get to the International Hotel from the Brno airport

From bus station Letiště Tuřany (Airport Tuřany) by bus nr. 76 to tram station Hlavní nádraží (Main Railway Station), the change for tram nr. 4 to  tram station Česká.

How to get to the International Hotel from the Main Bus Terminal Zvonařka

From Zvonařka Main Bus Terminal by tram nr. 12 to tram station Česka.

Useful maps: From the Main Railway station to the International Hotel 
                    From Česká to  the International Hotel
                    From the Hotel Grand - Student Agency bus station to the International Hotel


The conference is realized under the patronage of the Mayor of the City of Brno,

Petr Vokřál and with support by the City of Brno.









Abstracts and Posters

Book of Abstracts is HERE to download.